Acta anaesthesiologica Belgica
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Acta Anaesthesiol Belg · Jan 1988
Clinical Trial Controlled Clinical TrialEfficacy of lorazepam oral fast dissolving drug formulation (FDDF) in anesthesia premedication in adults: a double-blind placebo controlled comparison.
Lorazepam 4 mg oral fast dissolving drug formulation was compared to placebo in a double-blind study as premedicant in adult anesthesia. Lorazepam induced in this trial a marked relief of anxiety after 60 minutes without changes in vital parameters nor in reflex activity or muscle tonus. Anterograde amnesia was present in about 60 percent of the patients. ⋯ Postoperative residual effects on attention, cognitive, somatic and visceral functions were present till 5 hours postmedication. Lorazepam FDDF (fast dissolving drug formulation) appeared to be an effective and clinically safe premedicant for its good anxiolytic and amnestic effect and its high acceptance by the patients. Its use is not recommended for outpatient anesthesia because it prolongs recovery from anesthesia.
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Acta Anaesthesiol Belg · Jan 1988
Comparative Study Clinical Trial Controlled Clinical TrialAlizapride in the prevention of postoperative vomiting. A double-blind comparison.
Alizapride 50 mg intravenously was compared with placebo in a double-blind trial on 170 women undergoing planned soft tissue surgery under general anesthesia. Alizapride or placebo was given intravenously about 20 minutes before the end of the operation. A second and a third prophylactic dose was administered 4 and 8 hours after the first injection. ⋯ In the alizapride group there was less retching or emesis than in the placebo-group and the difference was statistically significant. However, there was still a significant incidence of 34% of postoperative vomiting in the alizapride group. There were no effects on heart rate or on respiratory rate but small changes of blood pressure after the first and second prophylactic injection of alizapride have been noted.
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Acta Anaesthesiol Belg · Jan 1988
ReviewThe modifying effect of anesthetic technique on the metabolic and endocrine responses to anesthesia and surgery.
In spite of the fact that our knowledge on the release mechanisms of the surgical stress response is rather incomplete, several techniques are available to modulate the response. However, at present it appears that no technique is capable to effectively suppress all aspects of the injury response and the widespread use of the term "stress free anesthesia" in surgery is therefore not valid. However, continuous administration of local anesthetic agents in the epidural space is the most effective technique in so far as reduction of the stress response is concerned. ⋯ The cumulative experience from these studies have demonstrated an advantageous effect on postoperative morbidity parameters such as blood loss, postoperative thromboembolic complications, pulmonary infective complications, gastrointestinal motility, postoperative hospital stay, etc. The most pronounced effect on morbidity in these studies is in procedures where regional anesthesia has also been demonstrated to be most effective on the surgical stress response. However, whether this is a causal relationship or a coincidental event, has not been finally answered.(ABSTRACT TRUNCATED AT 250 WORDS)