Acta anaesthesiologica Belgica
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Acta Anaesthesiol Belg · Jan 1988
Comparative Study Clinical Trial Controlled Clinical TrialAlizapride in the prevention of postoperative vomiting. A double-blind comparison.
Alizapride 50 mg intravenously was compared with placebo in a double-blind trial on 170 women undergoing planned soft tissue surgery under general anesthesia. Alizapride or placebo was given intravenously about 20 minutes before the end of the operation. A second and a third prophylactic dose was administered 4 and 8 hours after the first injection. ⋯ In the alizapride group there was less retching or emesis than in the placebo-group and the difference was statistically significant. However, there was still a significant incidence of 34% of postoperative vomiting in the alizapride group. There were no effects on heart rate or on respiratory rate but small changes of blood pressure after the first and second prophylactic injection of alizapride have been noted.
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Acta Anaesthesiol Belg · Jan 1988
Clinical Trial Controlled Clinical TrialA new lormetazepam galenical formulation for sublingual premedication.
This study reports a double-blind evaluation of a new formulation of lormetazepam for sublingual administration, given as a premedicant in 48 female patients undergoing minor gynecological procedures. Both patient's and nurse's assessments for anxiety and sedation were recorded at different times. ⋯ Nurses reported significant differences in sedation only, but already present at 30 minutes after premedication. The memory test showed no persistent effect of the benzodiazepine one day after surgery.
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Acta Anaesthesiol Belg · Jan 1988
ReviewIs there a place for regional anesthesia in pediatrics?--Yes!
Regional anesthesia has a central place in pediatrics. The neonate requires an analgesic, but not one which will produce respiratory depression. The older child undergoing intermediategrade surgery requires the best available analgesia, but without sedation and nausea. ⋯ Caudal block is particularly useful and, even when given in large doses, does not give rise to high plasma concentrations. Regional techniques are seen at their best when combined with light general anesthesia. The advantages of both these methods are then available for the benefit of the child, and the value of regional analgesia is further enhanced when supplementary intramuscular or oral analgesia is given regularly at specific times so that pain is prevented rather than relieved.