Acta anaesthesiologica Belgica
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Acta Anaesthesiol Belg · Jul 1975
Comparative StudyA comparison of the cardiovascular effects of enflurane, halothane, methoxyflurane and fluroxene during open cardiac surgery.
During open heart surgery hemodynamic changes due to 1.5% enflurane, 0.75% halothane, 0.18% methoxyflurane and 3.4% fluroxene have been compared. The following parameters have been measured: arterial pressure, heart rate, cardiac output, right and left atrial pressure, left ventricular pressure and dp/dt. The strongest effects were found with enflurane and halothane. ⋯ Because of its slow uptake methoxyflurane was followed by small hemodynamic changes in this study. The rapid acting fluroxene had caused only minor reductions of cardiac output, stroke volume and dp/dt. There was no decrease in peripheral resistance.
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Acta Anaesthesiol Belg · Jul 1975
Intravenous perfusion of adrenalin during enflurane (ethrane) anesthesia.
The effects of an IV perfusion of adrenaline were studied in three groups of patients. The first two groups were anesthestised with enflurane (Ethrane) and the perfusion of adrenaline was started either after stabilisation of cardiovascular parameters, or induction of anesthesia. The third group was anesthetised with halothane, and the perfusion of adrenaline was started after stabilisation of cardiovascular parameters. No significant statistical difference exists between the results obtained in the three groups, and particularly not concerning the incidence of arrythmias.
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The biotransformation of clinically important ester- and amide-type local anesthetic agents is reviewed with emphasis on their fate in man. Aspects considered include: 1 degree the contribution of biotransformation to overall pharmokinetic profiles and systemic safety; 2 degrees the effect of disease on biotransformation; 3 degrees biotransformation and fate in the neonate; 4 degrees pathways and products of biotransformation; 5 degrees pharmacokinetics of metabolites; 6 degrees pharmacological activity and toxicity of metabolites.
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Acta Anaesthesiol Belg · Jan 1975
First experiences with a documentation system via display terminals.
A documentation and monitoring system has been developed by members of the Department of Anesthesiology and the Department of Medical Data Processing of the Rheinisch-Westfälische Technische Hochschule Aachen. It is conceived in such a way that it should cover all the needs of the department, which is to say that every anesthesia done by a staff member should be documented, supervised and assisted by the computer service. ⋯ They display both alphanumerics and graphics in four different colors and modes. Information is entered in the system via so-called masks, which contain a larger section of information, and by on-line data recording.