Aǧrı : Ağrı (Algoloji) Derneği'nin Yayın organıdır = The journal of the Turkish Society of Algology
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The term adjuvant analgesics describes any drug with a primary indication other than pain, but with analgesic properties in some painful conditions. Adjuvant analgesics often are administered as first-line drugs in the treatment of chronic non-malignant pain. ⋯ Antidepressants, anticonvulsants, neuroleptics, antiarrythmics, antihistaminics, NMDA receptor-antagonists, steroids, muscle relaxants, bisphosphonates, and radiopharmaceuticals are adjuvant agents. This article reviews the evidence supporting the use of adjuvant analgesics for the treatment of pain and emphasizes medical dosages, side effects, and drug interactions.
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Migraine is an episodic headache disorder accompanied by various neurological, gastrointestinal and autonomic changes. In one fifth of the migraineurs, a neurological disturbance (visual, sensory or motor) appears during or before the development of the headache called migraine aura. ⋯ CSD was proposed to be the underlying phenomenon of the migraine aura as it propagates at a similar velocity with visual scotomata and the transient cortical oligemia seen in migraineurs during the aura phase. This data, enabling a better understanding of migraine pathophysiology, will result in new insights into the treatment of other neurological disorders such as cerebrovascular disorders, transient global amnesia, traumatic brain injury, in whose pathophysiology CSD is supposed to take part, beside the treatment of migraine itself.
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Randomized Controlled Trial
The effect of 3-in-1 femoral nerve block with ropivacaine 0.375% on postoperative morphine consumption in elderly patients after total knee replacement surgery.
Total knee replacement (TKR) is one of the most painful orthopedic surgical procedures. This study was aimed to investigate the effect of a single-shot preoperative 3-in-1 femoral nerve block on postoperative pain by using 0.375% ropivacaine, and on the consumption of morphine by using PCA following the TKR surgery. Side effects were also evaluated in this setting. 34 patients were included in this study. ⋯ The morphine requirement was significantly lower in Group R at 12, 18, 24, 48 hr after TKR (p<0.001). Side effects were also lower in this group. Preoperative single-shot 3-in-1 FNB with 40 cc of ropivacaine 0.375% provides better VAS scores, less morphine consumption and fewer side effects in elderly patients when compared to the group with no block.
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The mechanisms responsible for neuropathic pain are not fully understood. Most treatment modalities are ineffective or insufficient for this important clinical condition. Better understanding of pain mechanisms and opioid drug action has widened the indications for opioids in pain therapy of non-malignant pain including neuropathic pain. ⋯ Pain reduction was good throughout the study. Severe side effects did not occur. TDF was effective and well tolerated in the treatment of chronic neuropathic pain of non-malignant origin.
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The purpose of this study was to investigate the nurses' ain related knowledge, attitude and clinical decision making skills. Three instruments were used in the study: (1) Nurses' Introduction Form, (2) The Nurses' Knowledge and Attitudes Questionnaire and (3) Clinical Decision Making Survey Questionnaire developed by McCaffery and Ferrell was translated into Turkish and used with permission. The results showed that many nurses have inadequate knowledge about pain assessment and management, nurses' (% 47.4) did not observe patient's behaviors to determine/assess the patient's intensity of pain and % 74.5 of nurses' did not use pain assessment scales to measure the patient's pain.