World journal of gastroenterology : WJG
-
World J. Gastroenterol. · Jul 2010
Randomized Controlled Trial Multicenter StudyCetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial.
To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). ⋯ This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC.
-
World J. Gastroenterol. · Jun 2010
Vitamin D receptor gene polymorphisms and hepatocellular carcinoma in alcoholic cirrhosis.
To assess the relationship between vitamin D receptor (VDR) gene polymorphisms and the presence of hepatocellular carcinoma (HCC). ⋯ VDR genetic polymorphisms are significantly associated with the occurrence of HCC in patients with liver cirrhosis. This relationship is more specific for patients with an alcoholic etiology.
-
World J. Gastroenterol. · Jun 2010
Emodin enhances alveolar epithelial barrier function in rats with experimental acute pancreatitis.
To investigate the effect of emodin on expression of claudin-4, claudin-5 and occludin, as well as the alveolar epithelial barrier in rats with pancreatitis induced by sodium taurocholate. ⋯ Emodin attenuates pulmonary edema and inflammation, enhances alveolar epithelial barrier function, and promotes expression of claudin-4, claudin-5 and occludin in lung tissue samples from rats with acute pancreatitis.
-
World J. Gastroenterol. · May 2010
EditorialSedation and analgesia in gastrointestinal endoscopy: what's new?
Various types of sedation and analgesia technique have been used during gastrointestinal endoscopy procedures. The best methods for analgesia and sedation during gastrointestinal endoscopy are still debated. ⋯ Therefore there is an impulse for development of new approaches to endoscopic sedation. This article provides an update on the methods of sedation today available and future directions in endoscopic sedation.
-
World J. Gastroenterol. · May 2010
Comment LetterHerbal extracts as hepatoprotectants against acetaminophen hepatotoxicity.
Many plant-derived natural products have the potential to be hepatoprotective and therefore can be used to treat acute and chronic liver diseases. The challenge is to identify the most promising compounds and evaluate their protective mechanism. ⋯ The authors concluded that GM is hepatoprotective against acetaminophen-induced liver injury due to its antioxidant properties and anti-apoptotic capacity. We would like to discuss the limitations of this experimental approach and question the conclusion based on the data presented in this manuscript and the published literature.