Zhonghua wei zhong bing ji jiu yi xue
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Jan 2014
[Investigation of vasopressin response to increasing osmotic pressure in the late-phase of septic shock patients].
To investigate the vasopressin ( VP) response to increasing osmotic pressure in the late-phase of septic shock patients. ⋯ VP secretion to osmotic challenge was impaired and decreased in the late-phase of septic shock, prompting dysfunction in VP synthesis.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Jan 2014
Randomized Controlled Trial[The significance of lactic acid in early diagnosis and goal-directed therapy of septic shock patients].
To investigate the application of lactic acid in early diagnosis and goal-directed therapy of septic shock, and to provide reference for the early clinical diagnosis and treatment of septic shock. ⋯ By blood lactic acid monitoring, inadequacy of organization perfusion i.e. septic shock can be found in the early stage, thus early intervention can be performed and improve resuscitation result and reduce the mortality of septic shock patients. Blood lactic acid ≥ 4 mmol/L can be used as one of the criteria for the diagnosis of septic shock, and 6-hour blood lactic acid < 2 mmol/L as a goal to guide shock treatment with obvious prognosis improvement.
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The present review concluded remarkable globe clinical achievements in the field of critical care medicine during 2013. Briefly, new international sepsis management guideline, high frequency oscillatory ventilation, hydroxyethyl starch, immune-nutritional therapy, fecal transplantation and infection controlling became the highlighting topics. Additionally, it is also worthy to note the apparent disparity in the results between meta-analyses suggesting a treatment advantage and following large-scale randomized trials that have failed to detect such differences in treatment outcomes. Nonetheless, we still expect the emerging of ongoing investigations may provide clarity in these area..
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Jan 2014
[Change of platelet parameters in septic shock patients].
To observe the changes in platelet parameters including platelet volume distribution width (PDW), platelet crit (PCT) and platelet large cell ratio (PLCR) in patients with septic shock, and to approach its predictive effect on prognosis to obtain the indexes predicting the prognosis quickly and conveniently. ⋯ Different change trends of platelet parameters can be seen between the non-survivors and survivors of septic shock patients. If PDW, PLCR and MPV show increased trend while PLT and PCT show decreased trend, a poor prognosis maybe indicated. MPV may be most useful in prognosis forecast because of its biggest AUC.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Jan 2014
[Protective effect of necrostatin-1 on the liver of rats with trauma induced hemorrhagic shock].
To investigate the effects of necrostatin-1( Nec-1) on the liver of rats with trauma induced hemorrhagic shock. ⋯ Nec-1 may be remarkable protect effect on the liver of rats with trauma induced hemorrhage shock and reperfusion, and the intrinsic mechanisms need further investigation.