Zhonghua wei zhong bing ji jiu yi xue
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Nov 2014
[Effect of hypothermia on TLR2/MyD88 signal pathway in lung tissue in rats with acute lung injury induced by lipopolysaccharide].
To investigate the effect of hypothermia on the expression Toll-like receptor 2 (TLR2), myeloid differentiation factor 88 (MyD88), nuclear factor-ΚBp65 (NF-ΚBp65), plasminogen activator inhibitor-1 (PAI-1) in the TLR2/MyD88 pathway in rats with acute lung injury (ALI) induced by lipopolysaccharide (LPS) inhalation. ⋯ Hypothermia can down-regulate the expression of TLR2 mRNA, MyD88 mRNA, NF-ΚBp65 protein and PAI-1 in the TLR2/MyD88 pathway to protect lung tissue of rats with ALI induced by LPS inhalation from injury.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Oct 2014
Randomized Controlled Trial[Effects of levosimendan on hemodynamics and cardiac function in patients with septic shock].
To evaluate the effects of levosimendan on hemodynamics and cardiac function in patients with septic shock. ⋯ Levosimendan can increase cardiac ejection function, reduce the heart blood and vascular preload, intrathoracic lung water, improve heart function and systemic hemodynamic indexes of patients with septic shock.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Oct 2014
[Values of mixed venous oxygen saturation and difference of mixed venous-arterial partial pressure of carbon dioxide in monitoring of oxygen metabolism and treatment after open-heart operation].
To explore the clinic values of early goal directed treatment (EGDT) with the target of mixed venous oxygen saturation (SvO₂) and difference of mixed venous-arterial partial pressure of carbon dioxide (Pv-aCO₂) in monitoring of oxygen metabolism and treatment for patients post open-heart operation. ⋯ EGDT with the target of SvO₂≥0.65 and Pv-aCO₂<6 mmHg improved the general condition and tissue hypoxia, shortened the time of machine ventilation and duration of hospitalization in ICU, and decrease the 7-day mortality.