Zhonghua wei zhong bing ji jiu yi xue
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Sep 2014
[Comparison of 3-hour and 30-minute infusion regimens for meropenem in patients with hospital acquired pneumonia in intensive care unit: a randomized controlled clinical trial].
To Compare the clinical efficacy and safety of meropenem with a 3-hour extended infusion or conventional 30-minute infusion regimen in treatment of hospital acquired pneumonia (HAP) in intensive care unit (ICU) patients. ⋯ Compared with conventional regime of 30-minute infusion of meropenem in the treatment of HAP in ICU patients, the clinical efficacy can be improved, the severity of the disease can be reduced, the recovery of organ failure and long-term prognosis can be improved with 3 hour extended infusion of meropenem.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Sep 2014
[The assessment of ultrasonic measurement of superior vena cava blood flow for the volume responsiveness of patients with mechanical ventilation].
To approach the evaluative effect of respiratory variation of superior vena cava peak flow velocity measured using transthoracic echocardiography (TTE) on fluid responsiveness in patients with mechanical ventilation. ⋯ Respiratory variations in superior vena cava peak velocity measured by TTE could assess fluid responsiveness in patients with mechanical ventilation.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Sep 2014
[Study of the mechanisms of curcumin on mitochondrial permeability transition of hepatocytes in rats with sepsis].
To study the effects of mitochondrial permeability transition (MPT) on hepatocyte apoptosis and mitochondrial damage, and investigate the effects of curcumin on MPT and the related mechanisms in septic rat. ⋯ MPT can lead to mitochondrial dysfunction and further cause hepatocyte apoptosis. Mechanism of effect of curcumin on MPT may be related to reduction of intracellular calcium concentration, promotion of anti-apoptotic Bcl-2 gene expression, inhibition of caspase-3 activation and Bax gene.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Sep 2014
[Effect of time elapsed on continuous pulse contour cardiac output measurement in septic shock patients].
To evaluate the effect of time elapsed on continuous pulse contour cardiac output (PCCO) measurement in septic shock patients. ⋯ Our study in septic shock patients suggests that the accuracy of PCCO will be decreased as the increase of the time interval for calibration. Transpulmonary thermodilution calibration should be performed again if hemodynamic changes or was inconsistent with the clinical presentation. It is suggested that re-calibration should be done within 8 hours.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Aug 2014
[The protective effect of valproic acid on myocardium in rats with lethal scald injury and its mechanism].
To investigate the protective effects of valproic acid (VPA) on myocardium in rats following lethal burn injury and its mechanism. ⋯ VPA can attenuate cardiac injury and improve survival in a rodent model of lethal burn injury. These protective effects may be due to its inhibitory effects on histone deacetylase and caspase-3 activation.