Zhonghua wei zhong bing ji jiu yi xue
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Nov 2014
[Analysis of characteristics and related risk factors of prognosis in elderly and young adult patients with acute respiratory distress syndrome].
To compare the characteristics and risk factors of prognosis between elder and young patients with acute respiratory distress syndrome (ARDS) in intensive care unit (ICU). ⋯ Higher APACHEII score and the number of organ dysfunction were independent predictors of worse outcome in elder ARDS patients. Higher APACHEII score was the independent predictor of worse outcome in young ARDS patients.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Nov 2014
[The application value of the procalcitonin clearance rate on therapeutic effect and prognosis of ventilator associated pneumonia].
To assess the disease severity and prognosis value by observing the kinetic change of serum procalcitonin (PCT) and PCT clearance rate (PCTc) in the patients with ventilator associated pneumonia (VAP). ⋯ The increased levels of PCT in patients with VAP were associated with the poor control of infection and may indicate the deterioration of VAP, it also can reflect the activity of lung infection in time. Keep observing the dynamic change of PCT and analyzing PCTc is more useful. The PCTc levels may provide evidence of disease progression and helpful in risk stratification in patients with VAP, and lower level of PCTc may accompany serious infection and predict poor prognosis.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Nov 2014
[Phenotype and functions of natural killer cells in septic patients and its clinical significance].
To investigate the possible mechanism of natural killer cells (NK cells) in immune dysfunction in sepsis by monitoring the phenotype and function of periphery NK cells in patients with sepsis. ⋯ It was showed by NK cell phenotype and function assay that the function of NK cells in patients with sepsis was impaired and led to a poor production of IFN-γ. The IFN-γ mediated immune dysfunction may be a main reason for the disorder of NK cell function, which laid the foundation of the clinical immune intervention practice to improve to NK cell function.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Nov 2014
[The significance of non invasive cardiac output monitoring system on evaluating circulatory and respiratory function in pig with acute respiratory distress syndrome].
To investigate the effect of non invasive cardiac output monitoring (NICO) system in pig model with acute respiratory distress syndrome (ARDS), and to provide experimental basis for clinical application. ⋯ NICO technique provides a useful and accurate non invasive estimation of CO and respiratory function.VD/VT provided by NICO can titrate the optimal PEEP in patients with ARDS.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Nov 2014
[Heparin attenuates lipopolysaccharide-induced acute lung injury by inhibiting nitric oxide synthase and transforming growth factor -β/Smad signaling pathway].
To investigate whether heparin has a beneficial effect on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in rats, and to explore the possible underlying mechanisms. ⋯ Heparin significantly ameliorated the lung injury induced by LPS in rats via the inhibition of nitric oxide synthase expression and the TGF-β/Smad pathway.