Nihon rinsho. Japanese journal of clinical medicine
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Review Comparative Study
[Cost-effectiveness of the treatment of reflux esophagitis: proton pump inhibitor versus histamine-2-receptor antagonist].
Gastroesophageal reflux disease(GERD) is a common condition and acid-suppressing agents are the mainstays of treatment. A clinical decision analysis comparing a proton pump inhibitor(PPI), lansoprazole and a histamine H2-receptor antagonist (H2RA), ranitidine for the treatment of reflux esophagitis in Japan was performed using a Markov chain approach. ⋯ The PPI first strategy is the preferred therapeutic approach for medical treatment of reflux esophagitis. We also recommend that prescription of PPIs for a one-month period be approved by the Japanese health insurance scheme.
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Hiatal sliding hernia is often found in aged patient and some of them contribute to the development of reflux esophagitis. We described the etiology of gastroesophageal reflux disease(GERD) briefly and mentioned the relationship between hiatal hernia and reflux esophagitis. The old patients suffers from GERD are accompanying hiatal hernia at the high rate. ⋯ We emphasize that we should not hesitate to perform the surgical treatment to the patients suffering from GERD with hiatal hernia or after gastrectomy because it is safe and bring them the better Q. O. L. after treatment.