Nihon rinsho. Japanese journal of clinical medicine
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Melanoma is one of the most immunogenic tumors. However, objective response of immunotherapies has remained less than 5%. Since suppressive immunoreactions in tumor microenvironment have been illustrated in the past decade, immunosuppressive molecules are supposed to be useful targets of antibody therapies. ⋯ PD-1 blockade also showed more safe and great durable antitumor reactivity. Anti-CD137 agonist antibody and anti-CD40 agonist antibody are also good candidates for melanoma therapy. These immunomodulating therapies are the most promising treatment to overcome immunosuppression of melanoma.