Nihon rinsho. Japanese journal of clinical medicine
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A potent, rapid acting potassium-competitive acid blocker, vonoprazan, is introduced for clinical use in Japan. A number of phase III clinical trials comparing the efficacy of vonoprazan with lansoprazole, showed non-inferior or superior effectiveness in a spectrum of acid-related diseases. ⋯ The adverse events across these trials were comparable with the standard dose of lansoprazole. As a consequence of profound acid suppression, serum gastrin during vonoprazan therapy rose to much higher levels than those during lansoprazole therapy, pointing to a requirement for the assurance of long-term safety of vonoprazan.