Polskie Archiwum Medycyny Wewnętrznej
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Pol. Arch. Med. Wewn. · Jan 2024
Hepatitis B virus coinfection in patients treated for chronic hepatitis C: Clinical characteristics, risk of reactivation with long-term follow-up and effectiveness of antiviral therapy.
Hepatitis B virus (HBV) and hepatitis C virus (HCV) share a similar transmission route, which increases coinfection odds and worsens clinical outcomes. ⋯ Neither the presence of HBV markers nor HBV reactivation during DAA treatment reduced effectiveness of the therapy. Our findings are important for future recommendations and guidelines on managing HBV/HCV coinfection.
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Pol. Arch. Med. Wewn. · Jan 2024
Observational StudyLower air ozone concentration is associated with the presence of clinical remission in type 1 diabetes diagnosed in adulthood: a prospective, observational study in Wielkopolska voivodeship, Poland.
Clinical remission in type 1 diabetes (T1D) results from metabolic compensation after insulin implementation and is caused by various factors. ⋯ Increased ozone level may exacerbate metabolic outcomes and reduce remission in T1D.
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Pol. Arch. Med. Wewn. · Jan 2024
Hospitalizations of sarcoidosis patients before and during the COVID-19 pandemic in Poland.
Sarcoidosis is a multisystemic granulomatous disease that mostly affects the lungs and lymphatic system. Due to its rarity and variable clinical course, analyses of factors related to sarcoidosis should be based on large databases and long observation periods. ⋯ Health care changes related to the outbreak of the COVID‑19 pandemic may have increased the health debt for inpatient sarcoidosis treatment. The occurrence of sarcoidosis in Poland may be related to demographic and territorial factors.
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Pol. Arch. Med. Wewn. · Jan 2024
The treatment regimens and disease activity could alter the salivary myeloperoxidase levels in patients with inflammatory bowel diseases.
Inflammatory bowel diseases (IBDs) present with alternating periods of exacerbation and remission; therefore, it is necessary to develop noninvasive diagnostic tools to control the disease activity and improve therapeutic effectiveness. Recently, we have found that patients with ulcerative colitis (UC) who qualified for biologic therapy had significantly lower salivary myeloperoxidase (MPO) levels. ⋯ Salivary MPO levels changed depending on the disease activity in the patients with UC. Decreased MPO concentration in the saliva could be a predictor of clinically active UC.