Polskie Archiwum Medycyny Wewnętrznej
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Pol. Arch. Med. Wewn. · Jan 2024
Hepatitis B virus coinfection in patients treated for chronic hepatitis C: Clinical characteristics, risk of reactivation with long-term follow-up and effectiveness of antiviral therapy.
Hepatitis B virus (HBV) and hepatitis C virus (HCV) share a similar transmission route, which increases coinfection odds and worsens clinical outcomes. ⋯ Neither the presence of HBV markers nor HBV reactivation during DAA treatment reduced effectiveness of the therapy. Our findings are important for future recommendations and guidelines on managing HBV/HCV coinfection.
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Pol. Arch. Med. Wewn. · Jan 2024
Observational StudyLower air ozone concentration is associated with the presence of clinical remission in type 1 diabetes diagnosed in adulthood: a prospective, observational study in Wielkopolska voivodeship, Poland.
Clinical remission in type 1 diabetes (T1D) results from metabolic compensation after insulin implementation and is caused by various factors. ⋯ Increased ozone level may exacerbate metabolic outcomes and reduce remission in T1D.
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Pol. Arch. Med. Wewn. · Jan 2024
Serum microRNAs in young women with polycystic ovary syndrome and their association with glucose metabolism.
Polycystic ovary syndrome (PCOS) is associated with metabolic disturbances, such as insulin resistance and prediabetes, and the risk for their occurrence is especially increased in hyperandrogenic (HA) phenotypes of PCOS. Circulating microRNAs (miRNAs) may be involved in PCOS pathogenesis and regulation of metabolic processes. ⋯ The expression profile of circulating miRNAs is altered in patients with HA‑PCOS. Circulating miR‑27a and miR‑320 could serve as potential biomarkers of glucose metabolism disturbances in PCOS.