Polskie Archiwum Medycyny Wewnętrznej
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Pol. Arch. Med. Wewn. · Dec 2024
Expression of lncRNAs NEAT1, PACERR, and GAS5 can be associated with disease activity in rheumatoid arthritis patients.
Long noncoding RNAs (lncRNAs) have long been considered molecular noise within the transcriptome, but over time it has been shown that they perform many important biological functions and are associated with various inflammatory and autoimmune diseases, including rheumatoid arthritis (RA). ⋯ Circulating plasma lncRNAs may be considered as supporting molecular markers associated with RA activity and may be useful in identifying the disease exacerbation.
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Pol. Arch. Med. Wewn. · Dec 2024
Sex differences in cardiovascular outcomes in patients with acute pancreatitis.
The risk of cardiovascular disease increases in patients with acute pancreatitis (AP). However, it remains unknown whether this increase varies between sexes. ⋯ Men experienced more adverse cardiovascular outcomes than women in long follow‑up after AP, suggesting a need for sex‑specific management strategies in AP patients.
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Pol. Arch. Med. Wewn. · Dec 2024
Prognostic value of preoperative echocardiography in predicting myocardial injury after open abdominal aortic surgery.
Abdominal aortic aneurysms (AAAs) and peripheral arterial and aortic diseases (PAADs) are associated with increased risk of myocardial injury after noncardiac surgery (MINS). ⋯ Our study suggests that routine preoperative TTE may be moderately useful in the prediction of MINS among patients undergoing high‑risk vascular surgery.
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Pol. Arch. Med. Wewn. · Dec 2024
Does Epstein-Barr virus and intracellular Toll-like receptors affect the course of Hashimoto disease? Findings from studies on newly-diagnosed patients.
Epstein‑Barr virus (EBV) reactivation is increasingly recognized as a potential exacerbator of autoimmune diseases, including Hashimoto thyroiditis (HT). ⋯ These findings highlight the importance of considering both viral reactivation and TLR activity in the treatment of HT. Understanding the interplay between EBV and intracellular TLRs may lead to development of new therapeutic approaches to mitigate the impact of these factors on the disease progression. Further research is warranted to investigate the mechanisms underlying this interaction and its implications for treatment strategies.