Polskie Archiwum Medycyny Wewnętrznej
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Pol. Arch. Med. Wewn. · Feb 2025
Increased turnover of non-malignant T lymphocytes in patients with chronic lymphocytic leukemia may affect clinical progression.
A unique feature of chronic lymphocytic leukemia (CLL) is the increased number of circulating T cells preventing malignant B cells from undergoing apoptosis. Dysregulated expression of p27Kip1 and cyclin D2 (G1 phase regulators controlling lymphocyte survival) was examined in leukemic B cells but not non-malignant T cells. ⋯ CLL progression is associated with increased T-cell turnover triggered by dysregulated expression of G1 regulators, suggesting the involvement of the non-malignant T-cell compartment in disease pathogenesis and clinical outcomes.
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Pol. Arch. Med. Wewn. · Feb 2025
A supervised telemedical monitoring in the heart failure population in regions of social exclusion is associated with an improvement in functional capacity and quality of life.
Telemedicine is intended to provide medical care to patients in remote areas. ⋯ The applied telemedical model of care under the specialist's supervision was associated with an improvement in NYHA class and QoL in the HF population from regions of social exclusion.