Polskie Archiwum Medycyny Wewnętrznej
The most recent articles from:
Pol. Arch. Med. Wewn.
-
Pol. Arch. Med. Wewn. · Feb 2023
Thin-cap fibroatheroma and increased coronary intima-media thickness are associated with an altered arginine metabolites balance.
Arginase inhibition increases plasma citrulline and citrulline / ornithine (C/O) ratio, and reduces plasma ornithine and ornithine / arginine (O/A) ratio in an animal model of myocardial infarction (MI). ⋯ Enhanced arginase activity over nitric oxide synthase following ischemia was associated with the presence of TCFA in the culprit lesion, while a similar metabolic shift in the chronic phase correlated with a greater thickness of the intima‑media in the adjacent non‑culprit IRA segments.