European review for medical and pharmacological sciences
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Eur Rev Med Pharmacol Sci · Jan 2014
Pulmonary hypertension and beta blockers: where do we stand? Where are we going?
Pulmonary hypertension (PH) is a chronic, progressive debilitating disease and associated with poor prognosis despite the novel numerous treatment options. Beta-blockers constitute a cornerstone in left heart failure treatment; however, we still don't know the role of beta-blockers on PH and they are considered relatively contraindicated in patients with PH because of the possible negative effect on these patients' hemodynamics and exercise capacity. ⋯ As it is well-known, right heart function is the main prognostic determinants of the PH. The purpose of this chapter is to present the use of beta-blockers for the treatment of PH, the purported mechanisms of action, previously conducted animal studies and clinical trials.
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Eur Rev Med Pharmacol Sci · Jan 2013
Randomized Controlled TrialThe effects of ephedrine on maternal hypothermia in caesarean sections: a double blind randomized clinical trial.
The purpose of the study was to investigate the effect of bolus and the combination of bolus and infusion of ephedrine on maternal hypothermia which are used for treating maternal hypotension under spinal anaesthesia. ⋯ As a result, we found that combined bolus and infusion of ephedrine for treating maternal hypotension prevents maternal and neonatal hypothermia during caesarean section under spinal anaesthesia compared to bolus administrations alone.