Zhonghua yi xue za zhi
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Zhonghua yi xue za zhi · Aug 2016
[Association of Crohn's disease with transcobalamin Ⅱ gene polymorphisms and serum homocysteine, folate and vitamin B12 levels in Chinese patients].
To investigate the association of Crohn's disease (CD) with transcobalamin Ⅱ (TCN2) gene polymorphisms and serum homocysteine (Hcy), folate, and vitamin B12 levels in Chinese patients. ⋯ TCN2 rs1801198 mutation might be associated with increased risk of stricturing CD. TCN2 rs9606756 mutation might be a potential functional locus to affect CD susceptibility. Individuals carrying the haplotype (GG) formed by TCN2 (rs1801198 and rs9606756) seem to be at higher risk of developing CD. Hyperhomocysteinemia, folate deficiency, and vitamin B12 deficiency are prevalent in this cohort of CD patients of Han ethnicity from Zhejiang province. Both folate deficiency and vitamin B12 deficiency are independent risk factors for CD.
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Zhonghua yi xue za zhi · Aug 2016
Comparative Study[Comparison between micafungin and caspofungin for the empirical treatment of severe intra-abdominal infections in surgical intensive care patients].
To compare the efficacy and safety of micafungin with caspofungin for the empirical treatment of severe intra-abdominal infections in surgical intensive care patients. ⋯ The empirical treatment of echinocandins for patients with severe intra-abdominal infection and specific risk factors of IAC may be effective. The empirical treatment of micafungin and caspofungin were equally effective and safe.
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Zhonghua yi xue za zhi · Jul 2016
Randomized Controlled Trial[A study on diaphragm function after interscalene brachial plexus block using a fixed dose of ropivacaine with different concentrations].
To compare the effect of interscalene brachial plexus block (ISBPB) on the incidence of diaphragmatic paralysis, respiratory function and post-operative pain control using same dosage of local anesthetics diluted into two different volume and concentrations. ⋯ The use of 0.5% and 0.25% ropivacaine 50 mg for interscalene block provides similar effect on the incidence of diaphragmatic paralysis, changes in respiratory function and postoperative analgesia.
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Zhonghua yi xue za zhi · Jul 2016
[The protective effect of alpha-2 adrenergic agonist on cranial nerve in rats with brain injury].
To investigate the neuroprotective effect of α2 adrenergic agonist, dexmedetomidine on tumor necrosis factor α (TNF-α), interleukin-6 (IL-6) in brain tissue and serum S-100β protein level in traumatic brain injury rats. ⋯ Alpha-2 adrenergic agonist, dexmedetomidine could dramatically inhibit inflammatory reaction induced by traumatic brain injury in rats and protect brain tissue.
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Zhonghua yi xue za zhi · Jul 2016
[The causes and strategies for intraoperative rupture during clipping the anterior circulation aneurysms].
To investigate the causes and strategies for intraoperative rupture during clipping the anterior circulation aneurysms. ⋯ Adequate preoperative evaluation for the risk factors of intraoperative rupture and excellent microsurgical techniques can prevent intraoperative rupture of intracranial aneurysms. Controlling the bleeding quickly and dissecting and clipping the aneurysm after definitely know the anatomy of the aneurysm and surrounding vasculature could be the keys to deal with intraoperative aneurysm rupture.