Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
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Zhonghua Jie He He Hu Xi Za Zhi · Aug 2004
[Detection of the mRNA level of the subunits of amiloride-sensitive Na+ channel in human bronchial epithelium cells from patients with chronic obstructive pulmonary disease].
To investigate the role of epithelial amiloride-sensitive Na(+) channel (ENaC) in the pathogenesis of chronic obstructive pulmonary disease (COPD) and the effect of interleukin-4 (IL-4) and IL-6. ⋯ The increased ENaC alpha and gamma subunits in COPD group suggest that they may play a key role in the pathogenesis of COPD. Similarly, the increased ENaC alpha subunit mRNA in the smoking group indicates that smoking contributes to COPD development. IL-4 and IL-6 can influence the re-absorption of Na(+) in bronchial epithelial cells, which may be involved in the hypersecretion of COPD.
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Zhonghua Jie He He Hu Xi Za Zhi · Aug 2004
[Change of extravascular lung water in sheep with early acute respiratory distress syndrome].
To determine the change of extravascular lung water (EVLW) and the effect of positive end-expiratory pressure (PEEP) and cardiac output (CO) on EVLW in the sheep with early acute respiratory distress syndrome (ARDS). ⋯ EVLW in ARDS sheep increased significantly and remained at the same level during the early phase of ARDS. PEEP had a markedly effect in reducing EVLW, while the increase of CO induced by dobutamine did not significantly raise EVLW.