Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
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Conf Proc IEEE Eng Med Biol Soc · Jan 2013
A cepstral analysis based method for quantifying the depth of anesthesia from human EEG.
In this paper, a cepstral analysis based approach to measuring the depth of anesthesia (DoA) is presented. Cepstral analysis is a signal processing technique widely used especially for speech recognition in order to extract speech information regardless of vocal cord characteristics. The resulting index for the DoA is called index based on cepstral analysis (ICep). ⋯ All analyses are based on a single-channel electroencephalogram (EEG) of 10 human subjects. To validate the proposed technique, ICep is compared with bispectral index (BIS), which is the most commonly used method to estimate the level of consciousness via EEG during general anesthesia. The results show that ICep has high correlation with BIS, and is outstanding in terms of the Fisher criterion and offers faster tracking than BIS in the transition from consciousness to unconsciousness.
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Depth of anesthesia can be indirectly measured by Bispectral Index (BIS), therefore it is possible to administer propofol in a closed loop to maintain the optimal level of anesthesia while minimizing the dose to improve the postanesthesia recovery. High-Order Sliding-Mode control can be used to individualize drug dosing. In this study, the controller is tested with four in silico patients.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2013
Classification of EEG bursts in deep sevoflurane, desflurane and isoflurane anesthesia using AR-modeling and entropy measures.
A study relating signal patterns of burst onsets in burst suppression EEG to the anesthetic agent or anesthesia induction protocol is presented. A dataset of 82 recordings of sevoflurane, isoflurane and desflurane anesthesia underlies the study. 3 second segments from the onset of altogether 3214 bursts are described using AR model parameters, spectral entropy and sample entropy as features. ⋯ The results indicate that no clear cut distinction can be made between the burst patterns induced by the mentioned anesthetics although bursts of certain properties are more common in certain patient groups. Several directions for further investigations are proposed based on visual inspection of the recordings.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2013
Automated detection of sleep apnea in infants using minimally invasive sensors.
To address the difficult and necessity of early detection of sleep apnea hypopnea syndrome in infants, we present a study into the effectiveness of pulse oximetry as a minimally invasive means of automated diagnosis of sleep apnea in infants. Overnight polysomnogram data from 328 infants were used to extract time-domain based oximetry features and scored arousal data for each subject. These records were then used to determine apnea events and to train a classifier model based on linear discriminants. Performance of the classifier was evaluated using a leave-one-out cross-validation scheme and an accuracy of 68% was achieved, with a specificity of 68.6% and a sensitivity of 55.9%.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2013
A flexible algorithm framework for closed-loop neuromodulation research systems.
Modulation of neural activity through electrical stimulation of tissue is an effective therapy for neurological diseases such as Parkinson's disease and essential tremor. Researchers are exploring improving therapy through adjustment of stimulation parameters based upon sensed data. ⋯ The latter, known as the control policy algorithm, is the focus of this work. Because the optimal control policy algorithms for the nervous system are not fully characterized at this time, we have implemented a generic control policy framework to facilitate exploratory research and rapid prototyping of new neuromodulation strategies.