Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
-
Conf Proc IEEE Eng Med Biol Soc · Jan 2013
A brain-machine interface for control of burst suppression in medical coma.
Burst suppression is an electroencephalogram (EEG) marker of profound brain inactivation and unconsciousness and consists of bursts of electrical activity alternating with periods of isoelectricity called suppression. Burst suppression is the EEG pattern targeted in medical coma, a drug-induced brain state used to help recovery after brain injuries and to treat epilepsy that is refractory to conventional drug therapies. The state of coma is maintained manually by administering an intravenous infusion of an anesthetic, such as propofol, to target a pattern of burst suppression on the EEG. ⋯ We compute the BSP in real time from the EEG segmented into a binary time-series by deriving a two-dimensional state-space algorithm. We then derive a stochastic controller using both a linear-quadratic-regulator strategy and a model predictive control strategy. The BMI can promptly change the level of burst suppression without overshoot or undershoot and maintains precise control of time-varying target levels of burst suppression in individual rodents in real time.
-
Conf Proc IEEE Eng Med Biol Soc · Jan 2013
A simple and effective semi-invasive method for inducing local hypothermia in rat spinal cord.
Hypothermia has been shown to be an effective treatment for spinal cord injury. Local hypothermia is advantageous because it avoids inducing systemic side effects of general hypothermia while providing the opportunity for greater temperature reduction at the site of injury, which may contribute to increased neuroprotection. We report a new semi-invasive method for inducing local hypothermia in rats' spinal cords. ⋯ We also validated our method in control rats that received only a laminectomy. Furthermore, this method was able to reliably cool and rewarm the cord at a steady rate (Δ5.5°C in 30 min, or 0.2°C/min). Future work will include validating long-term functional improvements of injured rats after treatment and to apply local cooling to other spinal cord injury models, such as compression injuries.
-
Conf Proc IEEE Eng Med Biol Soc · Jan 2012
Strategies and synergies underlying replacement of vestibular function with prosthetic feedback.
This study investigated changes in movement strategies and muscle synergies when bilateral peripheral vestibular loss (BVL) subjects are provided prosthetic feedback of their pelvis sway during stance. Six BVL subjects performed 3, for them, difficult stance tasks: standing eyes closed, on a firm surface, on a foam surface, and standing eyes open on foam. Movement strategies were recorded as roll and pitch ratios of upper and lower body velocities with body-worn gyroscopes. ⋯ This is the first study that demonstrates how vestibular loss subjects achieve a reduction of sway during stance with prosthetic feedback. Unchanged movement strategies with reduced amplitudes are achieved with reduced antagonistic muscle synergies. This study has implications for the choice of feedback parameters (angle or velocity) and patient groups when using prosthetic devices to reduce sway of those with a tendency to fall.
-
Conf Proc IEEE Eng Med Biol Soc · Jan 2012
Evaluating the usability of a virtual reality-based Android application in managing the pain experience of wheelchair users.
Pain constitutes an important medical concern that can have severe implications to a wheelchair user's quality of life. Results from studies indicate that pain is a common problem in this group of individuals, having a reported frequency of always (12%) and everyday (33%). ⋯ As a result, in this paper we present an Android application (PainDroid) that has been enhanced with Virtual Reality (VR) technology for the purpose of improving the management of pain. Our evaluation with a group of wheelchair users revealed that PainDroid demonstrated high usability among this population, and is foreseen that it can make an important contribution in research on the assessment and management of pain.
-
Conf Proc IEEE Eng Med Biol Soc · Jan 2012
Controlled Clinical TrialPerformance of respiratory pattern parameters in classifiers for predict weaning process.
Weaning trials process of patients in intensive care units is a complex clinical procedure. 153 patients under extubation process (T-tube test) were studied: 94 patients with successful trials (group S), 38 patients who failed to maintain spontaneous breathing and were reconnected (group F), and 21 patients with successful test but that had to be reintubated before 48 hours (group R). The respiratory pattern of each patient was characterized through the following time series: inspiratory time (T(I)), expiratory time (T(E)), breathing cycle duration (T(Tot)), tidal volume (V(T)), inspiratory fraction (T(I)/T(Tot)), half inspired flow (V(T)/T(I)), and rapid shallow index (f/V(T)), where ƒ is respiratory rate. ⋯ We proposed the evaluation of these parameters using classifiers as logistic regression (LR), linear discriminant analysis (LDA), support vector machines (SVM) and classification and regression tree (CART) to discriminate between patients from groups S, F and R. An accuracy of 93% (98% sensitivity and 82% specificity) has been obtained using CART classification.