The Journal of the Association of Physicians of India
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J Assoc Physicians India · May 1993
Comparative StudyEffect of calcium channel antagonists on cholinergic bronchial responsiveness in asthma.
Bronchial responsiveness to methacholine was studied in 23 stable asthmatics before and after nifedipine and diltiazem. There was no significant bronchodilatory effect of either calcium channel antagonists. ⋯ The mean ratio of PC20 after diltiazem over baseline was 3.27 +/- 3.55. The results suggest that although both calcium channel antagonists have no influence on normal basal bronchomotor tone, diltiazem does significantly protect against cholinergic stimulation.