The Journal of the Association of Physicians of India
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J Assoc Physicians India · Oct 2003
Case ReportsReversible leg ulcer due to hydroxyurea in a case of chronic myeloid leukemia.
The cutaneous side effects of hydroxyurea are lesser known complication of long term hydroxyurea therapy in myeloproliferative disorders. We report a non-diabetic patient, who developed hydroxyurea dermopathy (leg ulcers) during long-term treatment with hydroxyurea for chronic myeloid leukemia (CML). The time course of the development of ulcers and its healing suggests that these resulted from the direct toxicity of hydroxyurea. We aim to increase clinical awareness of this problem.