The Journal of the Association of Physicians of India
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J Assoc Physicians India · Sep 2009
Multi-drug resistant Pseudomonas aeruginosa and Acinetobacter baumannii infections among hospitalized patients: risk factors and outcomes.
Pseudomonas aeruginosa [PA] and Acinetobacter baumannii [AB] are important nosocomial pathogens in health care settings. Treatment is complicated by multi-drug resistance [MDR]. Increasing resistance to carbapenems mediated by metallobetalactamase [MBL] and other mechanisms is a cause for concern because they adversely affect clinical outcomes and add to treatment costs. This study was undertaken to determine the prevalence of MBL production in carbapenem-resistant isolates and to study the factors influencing the clinical outcomes of infections. ⋯ MBL-mediated carbapenem resistance in PA and AB is a significant threat in hospitalised patients. It should be addressed with infection control measures, surveillance and alternative new therapeutic strategies.
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We present a rare disease condition Hermansky-Pudlak syndrome in a 33-year-old male. He was born of a consanguineous marriage, had occulo-cutaneous albinism, nystagmus, decreased visual acuity, refractory errors, pulmonary fibrosis and granulomatous inflammation of the colon. In spite of all the classical features of this genetic disorder he was labeled to have disseminated tuberculous infection with a drug resistant strain for many years till the actual diagnosis was made on the basis of a strong clinical suspicion. We report this rare condition which might be misdiagnosed as tuberculosis.