The Journal of the Association of Physicians of India
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J Assoc Physicians India
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J Assoc Physicians India · Apr 1998
Comparative Study Clinical TrialHerpes zoster and post-herpetic neuralgia--a clinical trial of aspirin in chloroform for anodyne.
Pain associated with Herpes Zoster (HZ) and Post-herpetic Neuralgia (PHN) has been a challenging task to manage with ease. Topical aspirin dissolved in chloroform is an effective means of reducing pain due to HZ and PHN in most patients. The locus of pain origin and analgesia induced by topical aspirin is supposed to be at cutaneous free nerve ending pain receptors. ⋯ Most of the patients experienced relief of pain within 1-5 minutes after the aspirin-chloroform application. Maximum relief was achieved in about 30-40 minutes and persisted for 5-6 hrs. In the beginning 3-4 applications were required but frequency decreased gradually as the pain abated.