Revista médica de Chile
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Revista médica de Chile · Mar 2002
[Seroprevalence of antibodies against hantavirus in 10 communities of the IX Region of Chile where hantavirus infection were diagnosed].
Thirty six cases of clinical Hantavirus Cardiopulmonary Syndrome occurred in the IX Region of Chile. Most of these patients were young males, farm or timber workers, who lived near the Andes Mountain chain. ⋯ Prevalence of Hantavirus antibodies correlated with the geographic zone (Andes Mountain chain), overgrowth of wild rodents and exposure to rodent-infested environments.
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Amyloidosis is a rare disease characterized by the pathological deposit of extracellular proteins in organs or tissues. We report a 78 years old female with a history of euthyroid goiter and carpal syndrome, that presented complaining of weight loss and the sensation of a big and rough tongue. ⋯ A bone marrow biopsy showed plasma cell infiltration. The patient was treated with melphalan and prednisone, but she deteriorated progressively and died 14 months after the diagnosis.
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Revista médica de Chile · Jan 2002
[Association between cleft lip/palate phenotype and non syndrome microsatellite markers located in 6p, 17q and 19q].
In the search of the major genes responsible for the genetic etiology of Nonsyndromic Cleft Lip and Palate (NSCLP), an association study between this malformation and four molecular markers, F13A1 and EDN1 (6p), D17S579 (17q) and BCL3 (19q), was done. ⋯ Our results support the hypothesis of the existence of cleft susceptibility regions in 6p and 17q. The small significance of BCL3, suggests that ethnicity can influence the interactions between involved genes.
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Revista médica de Chile · Dec 2001
Review[Febrile neutropenia in the child with cancer. Current concepts about risk assessment and selective management].
The risk for invasive bacterial infection (IBI) in cancer pediatric patients with febrile neutropenia, is variable. Clinicians worldwide are increasingly considering selective strategies for children at low risk for IBI, including shortened antimicrobial course, early hospital discharge, oral antimicrobial treatment, and management as outpatients. These strategies would significantly benefit these children and health care systems. ⋯ During 1996-1997 we identified risk factors of IBI in a group of 447 febrile neutropenic episodes. During 1999-2000 we validated these risk factors in a prospective study that included 263 febrile neutropenic episodes. A model of risk prediction was developed and is currently being evaluated for the selection of low risk patients who are treated as inpatients for 24 hours, followed by outpatient treatment.
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Revista médica de Chile · Oct 2001
[The six minute walking test elicits lung hyperinflation in patients with severe chronic obstructive lung disease].
Exercise tolerance in patients with COPD is highly variable and poorly related to airways obstruction assessed by FEV1. These patients develop dynamic hyperinflation (DH) during an incremental exercise test which can be evaluated through a reduction in inspiratory capacity (IC). ⋯ Our results demonstrate that a moderate exercise such as the walking test induces DH and hypoxemia in patients with COPD and FL and stresses the importance of assessing DH by measuring IC in these patients.