Revista médica de Chile
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Revista médica de Chile · Jun 2024
[Epidemiological Surveillance of Mumps Virus Infections in Chile: Laboratory Diagnosis During the Occurrence of the 2018 and 2019 Outbreak].
Mumps infections primarily affect childhood and the hallmark of infection is swelling of the parotid glands. The mumps cases decreased noticeably in Chile with the introduction of the triple virus vaccine. ⋯ The laboratory findings were essential for the accurate diagnosis of cases and the establishment of the outbreak by the epidemiological surveillance program.
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Revista médica de Chile · Jun 2024
Review Case Reports[Review of Multiple Endocrine Neoplasia Type 1 Based on a Clinical Case].
Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant disease with an estimated prevalence of 2 per 100,000. This disease is caused by a mutation in the tumor suppressor gene MEN1, which is located on chromosome 11 and codifies the menin protein. It is characterized by a predisposition of parathyroids, enteropancreatic, and anterior pituitary tumors, affecting the quality of life and lifespan of those who have the disease. ⋯ Pancreatic and parathyroid surgery were performed, and function substitution therapies were initiated. Discussion: The diagnosis is established in the presence of two or more defining NEM1 tumors or at least one associated with compatible genetic testing or a first-degree relative with a history of MEN1. Screening and surveillance in patients with confirmed MEN1 diagnosis would enable the reduction of the disease burden, with a nonclear impact on lifespan.
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Revista médica de Chile · Jun 2024
Case Reports[Autologous Stem-Cell Transplantation without Transfusion Support in Jehovah's Witness Patients. A case series].
Autologous Stem-Cell Transplantation (ASTC) has proven efficacy in several hematological malignancies. The greatest antineoplastic effect achieved with intensified chemotherapy is associated with severe myelotoxicity. The infusion of autologous hematopoietic precursors and transfusion support during the period of aplasia reduces the time and depth of cytopenias, decreasing the risk of bleeding, anemia and life-threatening infections. ⋯ Despite critical hemoglobin and platelet values observed, no serious complications or treatment-related mortality were observed. At the time of the report, all patients were alive and without progression of their neoplasms. Autologous stem-cell transplantation without transfusion support is feasible in centers with experience in this procedure and can benefit JW among other populations.