Otolaryngologia polska. The Polish otolaryngology
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Polyps within the nose and nasal sinuses are symptoms of both local conditions such as chronic bacterial or fungal rhinosinusitis, and systemic diseases such as cystic fibrosis, hypogammaglobulinemia, NSAID hypersensitivity syndrome, bronchial asthma as well as Kartagener's syndrome, Young's syndrome, Churg-Strauss' syndrome and Woakes' syndrome. The pathomechanism responsible for formation of nasal polyps remains a matter of dispute as well as the subject of numerous studies. Despite the proven role of metalloproteinases and their inhibitors in the pathomechanism of inflammation, the role of their respective polymorphisms has not been fully confirmed to date. ⋯ The 1G/2G polymorphism at position -1607 of the MMP1 gene may impact patients' predisposition to chronic rhinosinusitis with nasal polyps. Polymorphic variants are consistent with overall morbidity and may constitute risk variants. The status of a carrier of mutated (G insertion) allele with regard to the 1G/2G polymorphism at position -1607 within the MMP1 gene may determine a pathological phenotype associated with a more severe clinical course of CRSNP+ including earlier onset and disease recurrence.