Acta paediatrica Scandinavica
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Acta Paediatr Scand · Mar 1983
Clinical Trial Controlled Clinical TrialChronic Pseudomonas aeruginosa lung infection in cystic fibrosis. A longitudinal study of immune complex activity and inflammatory response in sputum sol-phase of cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infections: influence of local steroid treatment.
A double blind controlled trial of Becotide (beclomethasone diproprionate) inhalations was carried out for treating cystic fibrosis patients with chronic P. aeruginosa lung infection to determine its efficacy and safety. The aim of the treatment was to diminish the inflammatory response in the lungs of these patients, a response which is initiated by an allergic type III reaction. ⋯ There was, however, a significant increase in the inflammatory parameters for all 26 cystic fibrosis patients when the trial period was over, compared to the insidious pulmonary destruction which takes place in the lungs of these patients, and it corresponded to a significant decrease (p less than 0.05) in forced vital capacity which took place at the same time. Therefore, chronic P. aeruginosa lung infection in these patients should be treated as efficiently as possible.
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Acta Paediatr Scand · Jan 1983
Endotoxin clearance by exchange blood transfusion in septic shock neonates.
The role of exchange transfusion with fresh whole blood in septic shock infants was evaluated. Endotoxin was positive in 8 of 10 infants and completely removed from 6 by exchange transfusion. ⋯ Staphylococcus aureus was cultured in the blood from 2 infants with negative reactions and one of them survived. These findings suggested that the clearance of endotoxin has an important role in exchange transfusion among septic shock neonates.
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Acta Paediatr Scand · Mar 1982
Metabolic control in children with insulin dependent diabetes mellitus assessed by hemoglobin A1c.
The glycosylated hemoglobin component, hemoglobin A1c, was estimated in 92 children with insulin dependent diabetes mellitus by an iso-electric focusing procedure during an observation period of 18 months. A significant correlation between hemoglobin A1c and the actual metabolic control according to clinical ratings was found. A seasonal variation in the concentration of the hemoglobin A1c was observed with the lowest level in the months of June and July consistent with an improved metabolic control in the diabetic children during the summer period. ⋯ Children with poorly controlled diabetes (initial hemoglobin A1c level above 12.5%) improved their carbohydrate tolerance shown by a significantly lower glycohemoglobin level at the end of the observation period. Consequently, hemoglobin A1c is particularly useful in the routine management of insulin dependent diabetic children in poor metabolic control. Frequent determinations are necessary since in these patients the glucose profiles are prone to great variations, which may lead to changes in the hemoglobin A1c concentration of about 1% in a week.
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Rickets was diagnosed clinically and confirmed radiologically in a preterm infant at 12 weeks of age, who despite therapy with vitamin D died. Four preterm infants who were subsequently admitted to the nursery had their biochemistry followed serially as controls. ⋯ Rickets was confirmed radiologically in only one of these four infants. Rising and markedly elevated plasma alkaline phosphatase activity appears to be common in this group of infants and may represent a physiological increase in osteoblastic activity and increasing bone mineralisation in what would have been the infants' 3rd trimester of pregnancy and immediate newborn period.