Mayo Clinic proceedings
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Mayo Clinic proceedings · Jan 2000
Psychosocial profile of adults with complex congenital heart disease.
Despite the increasing number of adults with congenital heart disease (CHD), little is known of the emotional life of these long-term survivors; hence, we undertook a study to establish a psychological profile of these individuals so as to optimize their care. ⋯ Listening to this selected group of patients offers insight that may be helpful to the clinical care of patients with CHD and other patients with lifelong disease.
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Antimicrobial prophylaxis is used by clinicians for the prevention of numerous infections, including sexually transmitted diseases, human immunodeficiency virus infection, tuberculosis, rheumatic fever, recurrent cellulitis, meningococcal disease, recurrent uncomplicated urinary tract infections in women, spontaneous bacterial peritonitis in patients with cirrhosis, influenza, malaria, infective endocarditis, pertussis, plague, anthrax, early-onset group B streptococcal disease in neonates, and animal bite wounds. Certain opportunistic infections such as Pneumocystis carinii pneumonia in immunocompromised patients also can be effectively prevented with primary antimicrobial prophylaxis. ⋯ To maximize its effectiveness, intravenous perioperative prophylaxis should be given within 30 to 60 minutes before the time of surgical incision. Antibiotic prophylaxis should be of short duration to decrease toxicity, antimicrobial resistance, and excess cost.
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Mayo Clinic proceedings · Jan 2000
ReviewTestosterone replacement and the physiologic aspects of aging in men.
Clinical and epidemiologic studies, along with basic scientific research, have shown a trend toward androgen deficiency in aging males. The focus of the clinical investigations described here is to determine whether testosterone deficiency is a physiologic cause of the aging process and whether testosterone replacement might prevent or ameliorate a decline in quality of life associated with age-related decline in physical and psychological functioning.
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Mayo Clinic proceedings · Jan 2000
Comparative StudyProstatic steroid 5 alpha-reductase, an androgen metabolic gene.
Prostate cancer risk is highest in African Americans, lowest in Asians, and intermediate in Caucasians and Latinos. The data clearly suggest that environmental and genetic factors are involved. Investigation of the genetic factors suggests that allelic variation in the SRD5A2 gene is partially responsible for the striking racial and ethnic variations in risk.