Mayo Clinic proceedings
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Mayo Clinic proceedings · Sep 2010
ReviewParaneoplastic syndromes: an approach to diagnosis and treatment.
Recent medical advances have improved the understanding, diagnosis, and treatment of paraneoplastic syndromes. These disorders arise from tumor secretion of hormones, peptides, or cytokines or from immune cross-reactivity between malignant and normal tissues. Paraneoplastic syndromes may affect diverse organ systems, most notably the endocrine, neurologic, dermatologic, rheumatologic, and hematologic systems. ⋯ This review focuses on the diagnosis and treatment of paraneoplastic syndromes, with emphasis on those most frequently encountered clinically. Initial literature searches for this review were conducted using PubMed and the keyword paraneoplastic in conjunction with keywords such as malignancy, SIADH, and limbic encephalitis, depending on the particular topic. Date limitations typically were not used, but preference was given to recent articles when possible.
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Mayo Clinic proceedings · Sep 2010
A more aggressive approach to emergency embolectomy for acute pulmonary embolism.
To examine operative outcomes after acute pulmonary embolectomy (APE), a recently adopted, more aggressive surgical approach. ⋯ The results of emergent APE are encouraging, particularly among patients without cardiopulmonary arrest. It should not be reserved for patients in extremis; rather, it should be considered for patients with right ventricular dysfunction that is an early sign of impending hemodynamic collapse.
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Mayo Clinic proceedings · Sep 2010
Multicenter StudyImpact of prevalent fractures on quality of life: baseline results from the global longitudinal study of osteoporosis in women.
To examine several dimensions of health-related quality of life (HRQL) in postmenopausal women who report previous fractures, and to provide perspective by comparing these findings with those in other chronic conditions (diabetes, arthritis, lung disease). ⋯ Previous fractures at a variety of bone locations, particularly spine, hip, and upper leg, or involving more than 1 location are associated with significant reductions in quality of life.