Mayo Clinic proceedings
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Mayo Clinic proceedings · Dec 2012
Effect of large tumor size on cancer-specific mortality in node-negative breast cancer.
To examine the relationship between large tumor size and breast cancer-specific mortality (BCSM), especially in a subset of patients with negative lymph nodes (LNs). ⋯ A relatively larger tumor size without LN involvement may be a surrogate for biologically indolent disease of distant metastasis. Our findings, if validated in other large databases, may provide better understanding of breast cancer biology.
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Mayo Clinic proceedings · Dec 2012
Review Historical ArticleHistory of the Rochester Epidemiology Project: half a century of medical records linkage in a US population.
The Rochester Epidemiology Project (REP) has maintained a comprehensive medical records linkage system for nearly half a century for almost all persons residing in Olmsted County, Minnesota. Herein, we provide a brief history of the REP before and after 1966, the year in which the REP was officially established. The key protagonists before 1966 were Henry Plummer, Mabel Root, and Joseph Berkson, who developed a medical records linkage system at Mayo Clinic. ⋯ We describe how the key protagonists of the REP have responded to challenges posed by evolving medical knowledge, information technology, and public expectation and policy. In addition, we provide a general description of the system; discuss issues of data quality, reliability, and validity; describe the research team structure; provide information about funding; and compare the REP with other medical information systems. The REP can serve as a model for the development of similar research infrastructures in the United States and worldwide.
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Mayo Clinic proceedings · Dec 2012
Meningitis with a negative cerebrospinal fluid Gram stain in adults: risk classification for an adverse clinical outcome.
To derive and validate a risk score for an adverse clinical outcome in adults with meningitis and a negative cerebrospinal fluid (CSF) Gram stain. ⋯ Adults with meningitis and a negative CSF Gram stain can be accurately stratified for the risk of an adverse clinical outcome using clinical variables available at presentation.
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Mayo Clinic proceedings · Dec 2012
Association of resident fatigue and distress with occupational blood and body fluid exposures and motor vehicle incidents.
To evaluate the effect of resident physicians' distress on their personal safety. ⋯ Exposures to BBF are relatively uncommon among internal medicine residents in current training environments. Motor vehicle incidents, however, remain common. Our results confirm the importance of fatigue and sleepiness to resident safety concerns. In addition, higher levels of distress may be contributory factors to motor vehicle crashes and other related incidents. Interventions designed to address both fatigue and distress may be needed to optimally promote patient and resident safety.