Mayo Clinic proceedings
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Mayo Clinic proceedings · Mar 2013
Randomized Controlled TrialLosartan added to β-blockade therapy for aortic root dilation in Marfan syndrome: a randomized, open-label pilot study.
To assess the tolerability and efficacy of the investigational use of the angiotensin II receptor blocker losartan added to β-blockade (BB) to prevent progressive aortic root dilation in patients with Marfan syndrome (MFS). ⋯ This randomized, open-label, active controlled trial mostly based on a pediatric population demonstrated for the first time that losartan add-on BB therapy is safe and provides more effective protection to slow the progression of aortic root dilation than does BB treatment alone in patients with MFS.
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Mayo Clinic proceedings · Mar 2013
Fresh frozen plasma dosing for warfarin reversal: a practical formula.
To provide a practical formula for fresh frozen plasma (FFP) dosing for warfarin reversal. ⋯ This formula provides a practical and accurate method for FFP dosing for warfarin reversal.
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Mayo Clinic proceedings · Mar 2013
Comparative Study Clinical TrialCombined use of the novel biomarkers high-sensitivity troponin T and ST2 for heart failure risk stratification vs conventional assessment.
To assess an innovative multimarker strategy for risk stratification of death in a real-life ambulatory heart failure (HF) cohort. ⋯ A multimarker strategy seems useful for stratifying risk in chronic HF. However, NT-proBNP in addition to the new-generation biomarkers hs-cTnT and hs-ST2 had a limited effect on risk stratification.
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Mayo Clinic proceedings · Mar 2013
Maximal estimated cardiorespiratory fitness, cardiometabolic risk factors, and metabolic syndrome in the aerobics center longitudinal study.
To examine the relationship between estimated maximal cardiorespiratory fitness (CRF) and metabolic syndrome (MetSyn). ⋯ Cardiorespiratory fitness demonstrated a strong inverse relationship with MetSyn in both sexes, with the strongest single associative component being waist circumference.