Mayo Clinic proceedings
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Mayo Clinic proceedings · Oct 2014
Multicenter StudyAssociation of coronary artery calcium and coronary heart disease events in young and elderly participants in the multi-ethnic study of atherosclerosis: a secondary analysis of a prospective, population-based cohort.
To evaluate the association of coronary artery calcium (CAC) and coronary heart disease (CHD) events among young and elderly individuals. ⋯ Increased CAC imparts an increased CHD risk in younger and elderly individuals. CAC is highly predictive of CHD event risk across all age groups, suggesting that once CAC is known chronologic age has less importance. The utility of CAC scoring as a risk-stratification tool extends to both younger and elderly patients.
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Mayo Clinic proceedings · Oct 2014
Case ReportsMild cognitive impairment and mild dementia: a clinical perspective.
Mild cognitive impairment and mild dementia are common problems in the elderly. Primary care physicians are the first point of contact for most patients with these disorders and should be familiar with their diagnosis, prognosis, and management. Both mild cognitive impairment and mild dementia are characterized by objective evidence of cognitive impairment. ⋯ Pharmacological treatments are of modest value in mild dementia due to Alzheimer disease, and there are no approved pharmacological treatments for mild cognitive impairment of any etiology. Nonetheless, new-onset cognitive impairment is a worrisome symptom to patients and families that demands answers and advice. If a patient is having difficulties managing medications, finances, or transportation independently, diagnosis and intervention are necessary to ensure the health and safety of the patient.
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To describe clinical and laboratory findings from the 2012 southeastern Minnesota pertussis outbreak. ⋯ The 2012 pertussis outbreak in southeastern Minnesota included multiple strains of B pertussis, all putatively lacking pertactin. Our findings may indicate decreased efficacy of (and waning immunity from) acellular vaccines as contributors to the outbreak.
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Mayo Clinic proceedings · Oct 2014
Review Meta AnalysisThe prognostic importance of weight loss in coronary artery disease: a systematic review and meta-analysis.
To assess the prognostic impact of weight loss on clinical outcomes in patients with coronary artery disease (CAD). ⋯ Whereas observational weight loss is associated with increased adverse cardiovascular events, intentional weight loss is associated with lower clinical events. These results suggest that the underlying mechanism of weight loss (ie, intentional or unintentional) affects its impact on subsequent risk in persons with known CAD.
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Mayo Clinic proceedings · Oct 2014
Multicenter StudyPrevalence of multimorbidity in a geographically defined American population: patterns by age, sex, and race/ethnicity.
To describe the prevalence of multimorbidity involving 20 selected chronic conditions in a geographically defined US population, emphasizing age, sex, and racial/ethnic differences. ⋯ Multimorbidity is common in the general population; it increases steeply with older age, has different patterns in men and women, and varies by race/ethnicity.