Mayo Clinic proceedings
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Mayo Clinic proceedings · Apr 2020
Editorial CommentHomeless With a Heart Attack in America-A Double Whammy.
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Mayo Clinic proceedings · Apr 2020
Sex-Specific Human Cardiomyocyte Gene Regulation in Left Ventricular Pressure Overload.
To assess gene expression in cardiomyocytes isolated from patients with aortic stenosis, hypothesizing that maladaptive remodeling and inflammation-related genes are higher in male vs female patients. ⋯ These findings provide novel insight into cardiomyocyte-specific molecular changes related to sex differences in pressure overload and a significant male-specific association between cardiac function and inflammation-related genes. Considering these sex differences may contribute toward a more accurate design of research and the development of more appropriate therapeutic approaches for both male and female patients.
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Mayo Clinic proceedings · Apr 2020
ReviewUpdate on Treatment of Clostridioides difficile Infection.
Clostridioides difficile infection (CDI) is the leading cause of health care-associated infections in the United States. The increasing incidence and recurrence rates of CDI together with its associated morbidity and mortality are great concerns. ⋯ Cited references were also used to identify relevant literature. This review focuses on the current standard of therapy and emerging therapies for CDI and summarizes the updated guidelines on treatment of CDI.
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Mayo Clinic proceedings · Apr 2020
Meta AnalysisAtrial Fibrillation Is Associated With Syncope and Falls in Older Adults: A Systematic Review and Meta-analysis.
To examine the potential association of atrial fibrillation (AF) to syncope and falls, we undertook a systematic review and meta-analysis given the increasing prevalence of AF in older adults as well as emerging data that it is a risk factor for dementia. ⋯ AF is independently associated with syncope and falls in older adults. Further studies are needed to delineate mechanistic links and to guide management to improve outcomes in these patients.