Mayo Clinic proceedings
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Mayo Clinic proceedings · Dec 2022
Portopulmonary Hypertension in Nontransplanted Patients: Results of the Largest US Single-Institution Registry.
To explore clinical characteristics, risk profiles, and outcomes of patients with portopulmonary hypertension (PoPH) who have contraindications to liver transplant (LT). ⋯ Patients with PoPH who did not undergo LT had a poor prognosis. This persisted despite use of PAH-specific therapies and significant improvements in hemodynamics, echocardiography parameters of right ventricle function, 6-minute walk distance, and World Health Organization functional class.
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Mayo Clinic proceedings · Dec 2022
Relative Survival With Early-Stage Breast Cancer in Screened and Unscreened Populations.
Relative survival and disease-specific survival are two statistics that measure net survival from a cancer diagnosis, excluding other causes of death. In most cases, these two rates are comparable. However, in some cancer types for which cancer screening is performed, relative survival is often greater than disease-specific survival. ⋯ The favorable outcomes observed in screen-detected breast cancers are at least in part attributable to the healthy user effect and overdiagnosis of indolent tumors. Therefore, survival rates may not accurately reflect the effectiveness of cancer screening. These findings have implications for counseling of patients and future clinical studies of active monitoring approaches in breast cancer.
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Mayo Clinic proceedings · Dec 2022
Urinary Sodium-to-Potassium Ratio and Incident Chronic Kidney Disease: Results From the Korean Genome and Epidemiology Study.
To evaluate the association of sodium-potassium intake balance on kidney function. ⋯ A low urinary Na/K ratio may relate with lower CKD development risk in adults with preserved kidney function.