Advances in gerontology = Uspekhi gerontologii / Rossiĭskai͡a akademii͡a nauk, Gerontologicheskoe obshchestvo
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Almost all the functions of a living organism have circadian oscillations. Disturbance of circadian rhythms can be either a reason or a consequence of a number of diseases. The article describes data on relationship of circadian rhythm and clock genes disturbances with type 2 diabetes mellitus, cardiovascular and neurodegenerative disease development in humans and animals.
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Randomized Controlled Trial
[Evidence of feasibility etoricoxib therapy in osteoarthritis in elderly patients].
The article presents the results of a study of clinical efficacy in the treatment of etorikoxib pain in patients with osteoarthritis of the knee and hip joints in elderly patients. The study involved 296 patients with gonarthrosis and coxarthrosis. It is shown that etoricoxib effectively relieves pain, has an advantage over other NSAIDs speed and severity of the analgesic and anti-inflammatory effect, positive impact on laboratory signs of inflammation, demonstrated good tolerability and a low incidence of side effects, does not require discontinuation of therapy.