Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
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Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi · Dec 2009
[BTLA Characterization and its association with disease progression in patients with chronic HIV-1 infection.].
To characterize the B and T lymphocyte attenuator (BTLA, CD272) expression on CD4(+); and CD8(+); T lymphocytes during chronic HIV-1 infection, and analyze the clinical significance for its expression and disease progression. ⋯ BTLA signaling pathway may play an important role in the unbalance between the stimulating and inhibitory signal which results in the general immune activation during chronic HIV-1 infection. Manipulation of BTLA inhibitory pathway may present an alternative strategy for overcoming immune activation for this disease.