Genomics, proteomics & bioinformatics
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Genomics Proteomics Bioinformatics · Oct 2016
ReviewPharmacogenomics of Drug Metabolizing Enzymes and Transporters: Relevance to Precision Medicine.
The interindividual genetic variations in drug metabolizing enzymes and transporters influence the efficacy and toxicity of numerous drugs. As a fundamental element in precision medicine, pharmacogenomics, the study of responses of individuals to medication based on their genomic information, enables the evaluation of some specific genetic variants responsible for an individual's particular drug response. ⋯ The current effort illustrates the common presence of variability in drug responses among individuals and across all geographic regions. This information will aid health-care professionals in prescribing the most appropriate treatment aimed at achieving the best possible beneficial outcomes while avoiding unwanted effects for a particular patient.