Clinical advances in hematology & oncology : H&O
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Clin Adv Hematol Oncol · Dec 2003
ReviewThe role of prophylactic cranial radiation in the treatment of non-small-cell lung cancer.
Patients with lung cancer face a substantial risk of developing brain metastases. Prophylactic cranial irradiation therapy has been demonstrated to significantly decrease the incidence of central nervous system metastasis and improve overall survival in patients with small-cell lung cancer. ⋯ However, the role of prophylactic cranial irradiation in patients with non-small-cell lung cancer is less well defined. As treatment modalities improve and patients live longer their risk of developing central nervous system recurrence increases, and methods to prevent this demand exploration.
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Antiphospholipid antibodies (APAs) have been associated with thromboembolic events. Since they were fi rst described in 1906, APAs have been the subject of multidisciplinary studies seeking to link them to potential pathophysiologic mechanisms. This review summarizes the different types of APAs, antigenic targets, clinical complications associated with APAs, and APA syndrome. In addition, the currently available methods for laboratory identification of lupus anticoagulants are discussed, as is the laboratory diagnosis of anticardiolipin antibodies.