The Tohoku journal of experimental medicine
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Tohoku J. Exp. Med. · Sep 1983
Comparative StudyEffects of pantethine and its metabolites on fatty acid oxidation in rat liver mitochondria.
The mechanism of the activating effect of pantethine [D-bis-(N-pantothenyl-beta-aminoethyl)disulfide] on fatty acid oxidation was investigated in rat liver mitochondria. Pantethine, pantetheine and 4'-phosphopantetheine activated three steps of fatty acid oxidation, i.e., acyl-CoA synthetase, carnitine, acyltransferase and intramitochondrial oxidation, to various extents. Although their effects may have been partly due to CoASH derived from them, they also had specific effects.