The Tohoku journal of experimental medicine
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Tohoku J. Exp. Med. · Nov 2008
Clinical TrialImprovement in medication compliance and glycemic control with voglibose oral disintegrating tablet.
Good compliance with hypoglycemic therapy is important for diabetes treatment, since positive relationship between medication compliance and glycemic control has been reported. To improve medication compliance, the oral disintegrating tablet technology that facilitates drug administration without water has been employed in various drugs, including voglibose, an alpha glucosidase inhibitor. In the present survey, we investigated safety profile of voglibose oral disintegrating tablet (VODT), and whether treatment with VODT results in improvement of medication compliance and glycemic control. ⋯ Medication compliance was improved after switching to VODT in 28.4% of patients who missed taking tablets more than one time a week during CVT treatment. A significant decrease in HbA(1C) levels was observed in patients whose medication compliance was improved after switching to VODT (P = 0.033), but there was no significant reduction in HbA(1C) levels in patients whose medication compliance did not change. In conclusion, the present survey suggests that the safety profile of VODT is comparable with that of CVT, and switching from CVT to VODT has positive impact on medication compliance which may lead to an improvement in glycemic control.
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Tohoku J. Exp. Med. · Nov 2008
Clinical TrialLow visual acuity is associated with the decrease in postural sway.
Vision contributes to upright postural control by providing afferent feedback to the cerebellum. Vision is generally classified into central and peripheral vision, but little is known about the respective role of central and peripheral vision for postural control with different visual acuity levels. This study examined the influence of visual acuity and visual field conditions on upright posture. ⋯ The low visual acuity group decreased their sway amplitude in antero-posterior direction using central plus peripheral visual information, but the high visual-acuity group did not. The high frequency sway was significantly smaller in the low visual-acuity group than that in the high visual-acuity group under the no vision and central vision conditions. These findings suggest the necessity of considering participants' visual acuity in examining the role of the visual information from the central and peripheral visual fields.