The Tohoku journal of experimental medicine
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Tohoku J. Exp. Med. · Apr 2001
Comparative StudyNormal tension glaucoma and primary open angle glaucoma associated with increased platelet aggregation.
On purpose of the present study was to evaluate platelet aggregation and fibrinolytic systems in patients with normal tension glaucoma (NTG) or primary open angle glaucoma (POAG). For platelet aggregation, we photoelectrophotometrically investigated adenosine diphosphate (ADP) or collagen-induced platelet aggregation in consecutively selected patients with glaucoma (22 patients with NTG and 13 patients with POAG) and 42 glaucoma free control subjects with normal ocular findings. The aggregation patterns of the patients' platelets reacted abnormally to ADP 1 microM or collagen 0.5 microg/ml as evidenced by secondary aggregation were compared with those of control subjects. ⋯ No control subjects showed abnormal secondary aggregation. In the fibrinolytic test, all the parameters examined showed within normal ranges, although the log10(TAT) value was higher in NTG than in POAG. Results of the present study suggested that increased platelet aggregation as defined by ADP or collagen induced abnormal secondary aggregation in vitro is frequently associated with glaucoma patients and this tendency is more apparent in NTG than that in POAG.
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Tohoku J. Exp. Med. · Mar 2001
Case ReportsEntrapment of the sensory branch of the radial nerve (Wartenberg's syndrome): an unusual cause.
Isolated neuropathy of the cutaneous branch of the radial nerve is a rarely recognized pathology. It was described in 1932 by Wartenberg, who suggested the name cheiralgia paraesthetica. The syndrome is described as known the entrapment of the superficial branch of the radial nerve. ⋯ The patient underwent bony spike resection after five months with ineffective conservative treatment. He has satisfied after this operation. The case was presented because of disappearing his preoperative complaints after the operation with respect to Wartenberg's syndrome constituted a rare cause of bone spike which has not been mentioned in the literature.
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The neurolytic celiac plexus block (NCPB) has been recommended for pain relief in patients with upper abdominal cancer by the WHO Cancer Pain Relief Program. In this article, we review the indications, techniques, and adverse effects of NCPB based on the previous findings in the literature and our own experience of 142 NCPBs during the past 11 years. No well-validated indication criteria for the NCPB have been available from invasive trials or non-invasive pain evaluations. ⋯ The diarrhea may counteract the morphine-induced constipation. NCPB relieves visceral pain in upper abdominal cancer with no serious adverse effects. We recommend this procedure to improve the quality of life of the patients suffering from abdominal cancer pain.
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Tohoku J. Exp. Med. · Sep 2000
Comparative StudyComparison of wiring techniques for bone fracture fixation in total hip arthroplasty.
The objective of this study was to investigate the effect of cerclage wire position and determine the number of wires necessary to prevent crack opening and stem subsidence following a proximal femoral fracture in cementless total hip arthroplasty. A cementless femoral stem one size larger than the templated size was inserted into each femur to initiate a proximal crack. A cerclage wire was wrapped around the fracture in one of two orientations: 1) parallel to the osteotomy (PO) and 2) normal to the fracture line (NF). ⋯ The mechanical evaluation of stem subsidence were verified by various computer simulations even using four wires. We have found that placement of the cerclage wires normal to the fracture line prevents stem subsidence and crack opening better than placement of the wires parallel to the osteotomy. Three cerclage wires, placed normal to the fracture line at three locations: 1) adjacent to the superior of the lesser trochanter, 2) adjacent to the inferior of the lesser trochanter and 3) 10 mm distal to the bottom of the lesser trochanter were necessary to achieve stability under higher loads.
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Tohoku J. Exp. Med. · Dec 1999
Risk factors and triggers of sudden death in the working generation: an autopsy proven case-control study.
In Japan, studies on the risk factors of sudden death in the working generation have been rarely carried out, especially among extremely rare cases of causative disease. Thus, the present study aimed to identify the risk factors and triggers of sudden death in cases whose causes of death were definitely proven by autopsy. We investigated the legal medical records for four years from May 1994 to February 1998. ⋯ Long-term stress was associated with an increased risk of sudden death due to acute cardiac dysfunction. It was also demonstrated that autonomic disturbance and stress were closely related to the occurrence of sudden death. Therefore, to prevent sudden death, it would be helpful to identify subjective symptoms to relieve such stress in some way.