Archives of neurology
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Archives of neurology · Nov 2008
Predicting clinical progression in multiple sclerosis with the magnetic resonance disease severity scale.
Individual magnetic resonance imaging (MRI) disease severity measures, such as atrophy or lesions, show weak relationships to clinical status in patients with multiple sclerosis (MS). ⋯ Combining brain MRI lesion and atrophy measures can predict MS clinical progression and provides the basis for developing an MRI-based continuous scale as a marker of MS disease severity.
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Archives of neurology · Oct 2008
Multicenter Study Comparative StudyPrevalence of vitamin d insufficiency in patients with Parkinson disease and Alzheimer disease.
A role for vitamin D deficiency in Parkinson disease (PD) has recently been proposed. ⋯ This report of 25(OH)D concentrations in a predominantly white PD cohort demonstrates a significantly higher prevalence of hypovitaminosis in PD vs both healthy controls and patients with AD. These data support a possible role of vitamin D insufficiency in PD. Further studies are needed to determine the factors contributing to these differences and elucidate the potential role of vitamin D in pathogenesis and clinical course of PD.
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Archives of neurology · Oct 2008
Multicenter Study Clinical TrialSodium oxybate for excessive daytime sleepiness in Parkinson disease: an open-label polysomnographic study.
Many patients with Parkinson disease (PD) have excessive daytime sleepiness and numerous nocturnal sleep abnormalities. ⋯ Nocturnally administered sodium oxybate improved excessive daytime sleepiness and fatigue in PD.
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Archives of neurology · Oct 2008
Predictors of outcome in warfarin-related intracerebral hemorrhage.
Intracerebral hemorrhage (ICH) associated with warfarin sodium therapy is becoming more common as the use of this medication increases in the aging population. ⋯ Lower level of consciousness at presentation and larger initial ICH volume predict poor prognosis in patients with warfarin-associated ICH. In our study population, INR at presentation was not associated with functional outcome.