The American journal of gastroenterology
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Am. J. Gastroenterol. · Jul 2015
Comparative StudyChromoendoscopy for Surveillance in Inflammatory Bowel Disease Does Not Increase Neoplasia Detection Compared With Conventional Colonoscopy With Random Biopsies: Results From a Large Retrospective Study.
Randomized trials demonstrated that chromoendoscopy is superior to white light endoscopy with random biopsy sampling (WLE) for the detection of dysplasia in patients with inflammatory bowel disease (IBD). Whether implementing chromoendoscopy can increase the detection of dysplasia in clinical practice is unknown. ⋯ Despite compelling evidence from randomized trials, implementation of chromoendoscopy for IBD surveillance did not increase dysplasia detection compared with WLE with targeted and random biopsies.
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Am. J. Gastroenterol. · May 2015
Randomized Controlled Trial Multicenter StudyA randomized, placebo-controlled trial of lubiprostone for opioid-induced constipation in chronic noncancer pain.
This multicenter, phase 3 trial evaluated oral lubiprostone for constipation associated with non-methadone opioids in patients with chronic noncancer-related pain. ⋯ Lubiprostone significantly improved symptoms of OIC and was well tolerated in patients with chronic noncancer pain.
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Am. J. Gastroenterol. · Apr 2015
Comparative StudyInflammatory bowel disease in immigrants to Canada and their children: a population-based cohort study.
The risk of inflammatory bowel disease (IBD) contributed by the environment can be elucidated by assessing the risk in migrants from low prevalence to Western countries. The incidence of IBD in immigrants to Canada and their Canadian-born children was compared with nonimmigrants. ⋯ Younger age at arrival to Canada increased the risk of IBD in immigrants. Canadian-born children of immigrants from some regions assumed the high Canadian incidence of IBD, indicating that the underlying risk is activated with earlier life exposure to the Canadian environment in certain groups.
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Am. J. Gastroenterol. · Apr 2015
Familial risk of inflammatory bowel disease: a population-based cohort study 1977-2011.
Estimates of familial risk of inflammatory bowel diseases (IBDs), Crohn's disease (CD), and ulcerative colitis (UC) are needed for counseling of patients and could be used to target future prevention. We aimed to provide comprehensive population-based estimates of familial risk of IBD. ⋯ The risk of IBD is significantly increased in first -, second-, and third-degree relatives of IBD-affected cases, with up to 12% of all IBD cases being family cases. The risk is particularly pronounced in young individuals.
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Am. J. Gastroenterol. · Apr 2015
Emergency department burden of constipation in the United States from 2006 to 2011.
Although constipation is typically managed in an outpatient setting, there is an increasing trend in the frequency of constipation-related hospital visits. The aim of this study was to analyze trends related to chronic constipation (CC) in the United States with respect to emergency department (ED) visits, patient and hospital characteristics, and associated costs. ⋯ The frequency of and the associated costs of ED visits for constipation are significant and have increased notably from 2006 to 2011.