Zhonghua yi xue za zhi = Chinese medical journal; Free China ed
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Zhonghua Yi Xue Za Zhi (Taipei) · Oct 2000
Randomized Controlled Trial Comparative StudyComparison of the efficacy and safety of oral granisetron plus dexamethasone with intravenous ondansetron plus dexamethasone to control nausea and vomiting induced by moderate/severe emetogenic chemotherapy.
Chemotherapy-induced nausea and vomiting can affect cancer patients' compliance with cytotoxic chemotherapy. Currently, there are some new antiemetic therapies for the treatment of chemotherapy-induced emesis. A single institution, randomized, open, parallel trial was done to compare oral granisetron plus intravenous (i.v.) dexamethasone with intravenous ondansetron for the prevention of moderate or severe emetogenic chemotherapy-induced acute and delayed emesis. ⋯ Oral granisetron plus i.v. dexamethasone and i.v. ondansetron plus i.v. dexamethasone are potentially equally effective antiemetic agents in the prevention of moderate or severe emetogenic chemotherapy-induced acute or delayed emesis. Oral granisetron with dexamethasone appears to be a suitable alternative antiemetic agent in cancer patients who receive moderately or severely emetogenic chemotherapy.
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Zhonghua Yi Xue Za Zhi (Taipei) · Jul 2000
Randomized Controlled Trial Comparative Study Clinical TrialComparison of bilevel positive airway pressure and volume ventilation via nasal or facial masks in patients with severe, stable COPD.
In the past decade, noninvasive positive pressure ventilation (NIPPV) has been successfully used in chronic obstructive pulmonary disease (COPD) with acute exacerbation. Nonetheless, its effect in stable COPD remains controversial. Theoretically, differences in the mode of ventilation such as pressure versus volume preset, or interfaces such as nasal versus full facial mask could have an impact on the efficacy of NIPPV. Few published studies have focused on this topic. ⋯ For patients with stable hypercapnic COPD, short-term use of BiPAP via either a nasal or facial mask markedly rests the inspiratory muscles, improves the respiratory pattern and reduces the sense of dyspnea for patients. In contrast, short-term use of PLV-100 via either a nasal or facial mask worsens the above parameters.
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Zhonghua Yi Xue Za Zhi (Taipei) · Nov 1999
Randomized Controlled Trial Comparative Study Clinical TrialComparison of recovery characteristics of sevoflurane and halothane for outpatient surgery in infants.
Sevoflurane, a newly approved potent inhaled anesthetic in Taiwan, provides rapid emergence from anesthesia in adults and children. Clinically, it is difficult to accurately assess the rate of recovery from anesthesia in infants. This study was designed to compare the emergence characteristics of halothane with those of sevoflurane having recourse to a respiratory agent monitor in infants undergoing outpatient surgery. ⋯ Sevoflurane is superior to halothane for rapid elimination in infant outpatient surgery as gauged by observation of end-tidal concentration elimination curves recorded with a respiratory agent monitor. No other postoperative side-effect was evident in sevoflurane anesthesia.
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Zhonghua Yi Xue Za Zhi (Taipei) · Aug 1998
Randomized Controlled Trial Clinical TrialEmergency medical resource use in Taipei city.
It is a worldwide trend to serve emergency patients at emergency department (EDs) staffed by board-certified emergency physicians (EPs). The question arises as to how many EPs are cost effective? This cannot be answered until utilization of emergency resources in the community is explored, so that appropriate plans for efficient ED use, staffing and training of EPs can be made. ⋯ VGH-T is a favorable training ground for EPs due to its high volume of adult and elderly, advanced life support eligible, ICU and high acuity patients. MMH is an ideal place for training in pediatric emergency medicine. Utilization of the 119 emergency response system is low. The number of patients with high acuity triage in Taipei City is low. However, Taipei City faces a shortage of acute care beds, especially ICU beds.
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Zhonghua Yi Xue Za Zhi (Taipei) · Jul 1997
Randomized Controlled Trial Clinical TrialImproved postoperative pain relief via preemptive analgesia in relation to heart rate variability for coronary artery bypass grafting: a preliminary report.
Sudden cardiac death remains to be the most devastating outcome for patients who undergo cardiac surgery. Surgical stress in combination with postoperative pain are key factors of such tragedy. Preemptive analgesia (PA) is supposed to provide optimal postoperative pain management, and epidural morphine infusion to provide effective pain relief and stress reduction after cardiac surgery. Heart rate (HR) variability seems to correlate to the survival of acute myocardial infarction (AMI) patients. This study was conducted to evaluate the benefits of PA for coronary artery bypass grafting (CABG) patients in the sense of improvement in postoperative respiratory and cardiovascular functions, and its correlation to HR and HR variability. ⋯ PA method through the use of epidural anesthesia along with morphine infusion provided better postoperative pain relief and more stable respiratory and cardiovascular functions in our patients with cardiac surgery. Although the differences in HR and HR variability between the control and the PA groups were not statistically significant throughout the period studied, the potential benefits of better understanding the relationship between postoperative pain control and HR variability justify further studies to be conducted.