Clinical and experimental pharmacology & physiology
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Clin. Exp. Pharmacol. Physiol. · Sep 1997
Psychomotor performance during initial stage of exposure to halothane, enflurane, isoflurane and sevoflurane in mice.
1. The dose-response relationship during the pre-anaesthetic and pre-equilibrium state of four inhalation anaesthetics (halothane, enflurane, isoflurane and sevoflurane) on fixed-ratio schedule-controlled behaviour was studied in mice. 2. ⋯ Sevoflurane did not increase schedule-controlled behavioural responses at any concentration. 4. The effect of subanaesthetic concentrations of inhalation anaesthetics on psychomotor performance can be evaluated as changes in the response rate in schedule-controlled behaviour.