Clinical and experimental pharmacology & physiology
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1. Cough is a primary defensive reflex that protects the airways from potentially harmful stimuli. 2. ⋯ Currently available therapeutics are mostly ineffective at suppressing excessive coughing. 4. In the present review, we describe the sensory neural pathways involved in cough, how these pathways may become dysfunctional in airway disease and the most recent advances that have been made in identifying future targets for cough suppression.