IEEE pulse
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Neural implantation of devices and the subsequent tissue response are complex and cascading physical and biological phenomena. Creation of reliable neural interfaces remains a significant challenge. Penetrating central nervous system interfaces persist as the most challenging to realize but continue to be the most attractive because of the information bandwidth advantages they provide. ⋯ The ultimate realization of reliable penetrating neural interfaces will require careful science and engineering approaches incorporating knowledge of relevant and critical biological, physical, and chemical factors, especially their interrelationship. In this article, we describe a comprehensive strategy to assess the reliability of penetrating central neural interfaces based on the biology and pathology of the injury and indwelling tissue responses. Our strategy involves a parallel, self-informing approach by simultaneous development of new in vitro and in vivo assessment techniques as well as using these state-of-the-art techniques to conduct accelerated lifetime assessments of neural interface degradation.
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When the Defense Advanced Research Projects Agency (DARPA) asks research questions, it goes big. This is, after all, the same agency that put together teams of scientists and engineers to find a way to connect the worlds computers and, in doing so, developed the precursor to the Internet. DARPA, the experimental research wing of the U. ⋯ Its focus with these projects is on its prime customer, the U. S. Department of Defense, but Ling acknowledged that technologies developed in its programs "certainly have potential to cascade into civilian uses."