Voprosy onkologii
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Examination of 127 patients with generalized prostate cancer established a low prophylactic effect of systematic treatment with strontium-39 chloride: it failed to alleviate pain in metastatic cancer, nor was it followed by longer mean survival. Repeat systematic radiotherapy is not indicated when palliative measures such as hormonal therapy, local radiotherapy and chemotherapy are still effective.
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A clinical test of strontium-89 chloride effect was carried out in 150 patients with bone metastases and bone pain from different patterns of tumor. Different types of bone lesions were considered. Pain-relieving effect was reported in 77%, irrespective of lesion gravity. ⋯ It mostly occurred in cases of lysis. Strontium-89 chloride therapy contributed to partial bone tissue repair. It is indicated as a component of complex treatment for bone metastases.
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While general cervical carcinoma morbidity is on the decline in most of the surveyed Russian Federation areas characterized by varying levels of industrial pollution, the heavily industrialized region of Salavat revealed a different tendency. Its level was 1.6 times (p<0.05) those in other areas. That was due to the morbidity of women aged 40-69 and even 20-29 and 30-39 years.
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Clinical Trial Controlled Clinical Trial
[Criteria for suppressive dosage of thyroxine administered in thyroid cancer].
The investigation was concerned with thyroxine therapy for suppression of thyrotrophin synthesis in 1,033 out of 1,544 (66.9%) patients treated for papillary thyroid cancer (hemithyroidectomy--429, thyroidectomy--1,115; 484 of the latter group received radioiodinetherapy postoperatively). Thyroxine 2-5.2 mg/body mass unit was administered for 1-10 yrs (average--4. yrs). Effective daily dose depended on extent of surgery: higher dosage was required after thyroidectomy than hemithyroidectomy, and it was significantly higher after radioiodinetherapy. ⋯ Also, an inverse relationship was established between suppressive dose and age. Male patients appeared to require more thyroxine per day than women. Suppressive dosage of thyroxine with regard to age, sex and treatment modality is suggested.