Seminars in thrombosis and hemostasis
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Semin. Thromb. Hemost. · Jan 1993
ReviewCoagulation and fibrinolysis in orthotopic liver transplantation: current views and insights.
Bleeding in OLT is related to two different mechanisms. There is no doubt that the extensive surgical trauma plays a critical role in the origin of serious bleeding. However, this bleeding can be aggravated by defects in the hemostasis system. ⋯ However, the effect of aprotinin and other antifibrinolytic agents has still to be confirmed by randomized clinical studies. Future scientific research should focus on the mechanisms underlying the hemostasis defects. It can be expected that these efforts may finally result in a further reduction in the usage of blood products during liver transplantation.
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Semin. Thromb. Hemost. · Jan 1993
Review Randomized Controlled Trial Comparative Study Clinical TrialAprotinin in orthotopic liver transplantation.